Young women are being discovered dead across the Old Town, all having suffered similarly gruesome ends. In the New Town, medical student Will Raven is about to start his apprenticeship with the brilliant and renowned Dr. Simpson. Simpson's patients range from the richest to the poorest of this divided city. His house is like no other, full of visiting luminaries and daring experiments in the new medical frontier of anaesthesia. It is here that Raven meets housemaid Sarah Fisher, who recognises trouble when she sees it and takes an immediate dislike to him. She has all of his intelligence but none of his privileges, in particular his medical education.
With each having their own motive to look deeper into these deaths, Raven and Sarah find themselves propelled headlong into the darkest shadows of Edinburgh's underworld, where they will have to overcome their differences if they are to make it out alive.